Adis Journals
Browse

File(s) not publicly available

Reason: No enhanced material

Benralizumab: First Global Approval

online resource
posted on 2018-03-28, 02:06 authored by Anthony Markham
Compliance with Ethical Standards

Funding: The preparation of this review was not supported by any external funding.

Conflicts of interest: Anthony Markham is a salaried employee of Adis/Springer, is responsible for the article content and declares no relevant conflicts of interest.

Additional information about this Adis Drug Review can be found here.

Abstract

Kyowa Hakko Kirin, AstraZeneca and subsidiaries are developing benralizumab (Fasenraä) – a fully humanised anti-interleukin-5 receptor alpha chain (IL-5Ra) monoclonal antibody – as a treatment of severe eosinophilic asthma and chronic obstructive pulmonary disease (COPD). Eosinophilia is a characteristic of certain asthma and COPD phenotypes and depletion of eosinophils has demonstrated therapeutic benefit. Benralizumab was recently approved by the US FDA as add-on maintenance therapy for patients with severe asthma who have an eosinophilic phenotype. This article summarizes the milestones in the development of benralizumab leading to this first approval for the treatment of severe eosinophilic asthma. Access to the full article can be found here.

© Springer International Publishing AG, part of Springer Nature 2018

History

Usage metrics

    Drugs

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC